Used as a large animal sedative, primarily in horses.Ī prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma.Īn alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea.Īn alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used less commonly in a wide variety of other animal species. Romifidine is a veterinary drug utilized as a sedative primarily in large animals, most frequently horses. Medetomidine is an intravenously available alpha-2 adrenergic agonist. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. Amitraz presents insect repellent effects and hence, it can be used as. It was generated in 1969 by the Boots Co. Drugs DrugĪ centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises.Īmitraz is a non-systemic acaricide and insecticide. Whether prazosin acts through altering vascular permeability or the immune response, or both, remains to be determined.Name Adrenergic alpha-2 Receptor Agonists Accession Number DBCAT002651 (DBCAT000921) DescriptionĬompounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. Treatment with prazosin was also able to suppress clinical and histological signs of EAE in animals sensitized by adoptive transfer with activated spleen or lymph node cells. Analysis of the effect of other adrenergic receptor antagonists supports the conclusion that the suppressive effect of prazosin is a consequence of blockade of the alpha 1-receptor since treatment with either the alpha 2-antagonist yohimbine or the beta-antagonist propranolol exacerbated the disease, whereas treatment with the long-acting mixed alpha 1/alpha 2-antagonist phenoxybenzamine had some suppressive activity. Suppression was more significant in females than in males and was a dose-dependent phenomenon. Prazosin, an antagonist of alpha 1-adrenergic receptors, has been found to suppress the clinical and histological expression of experimental autoimmune encephalomyelitis (EAE) in the Lewis rat.
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