![]() Absorbents which include no or small amounts of NaOH/KOH produce smaller quantities of compound A, but their CO 2 absorption capacity seems poorer. Compound A has a dose-dependent nephrotoxic effect in rats, although clinically adverse effects are rare. ![]() While Medisorb has the best ability to absorb CO 2, it alone produces compound A.Ĭonventional carbon dioxide (CO 2) absorbents containing strong bases (sodium hydroxide, NaOH and potassium hydroxide, KOH) can absorb CO 2 in a semi-closed anaesthetic circuits but also degrade sevoflurane to fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (CF 2 = C(CF 3)-O-CH 2F, compound A). In vivo, compound A (1.0% inspired sevoflurane) was detected only when using Medisorb. During exposure to 200 ml.min −1 CO 2 in vitro, the period until 1 kg of fresh soda lime allowed inspired CO 2 to increase to 0.7 kPa (as a mark of utilisation of the absorbent) was longer with Medisorb (1978 min) than with the other absorbents (1270–1375 min). The order of the color acceptability was similar: Sodasorb LF > Amsorb Plus = Medisorb > YabashiLime both initially and 16 h after CO 2 exhaustion. ![]() In vitro, the order of the dust amount was Sodasorb LF > Medisorb > Amsorb Plus = YabashiLime both before and after shaking. To evaluate the performance of four kinds of carbon dioxide (CO 2) absorbents (Medisorb ® GE Healthcare, Amsorb ® Plus Armstrong Medical, YabashiLime ® Yabashi Industries, and Sodasorb ® LF Grace Performance Chemicals), we measured their dust production, acceptability of colour indicator, and CO 2 absorption capacity in in vitro experimental settings and the concentration of compound A in an inspired anaesthetic circuit during in vivo clinical practice. ![]()
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